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Original Research
Online Published: 28 Aug 2014
 
RMJ. 2014; 39(3): 311-313


Efficacy of tranexamic acid in reducing blood loss during and after cesarean section

Nergis Taj, Ahsan Firdaus, Nadeem Akhtar, Muhammad Hamid Chaudhary, Sarah, Zunaira Bajwa, Ehsan Ullah.


Abstract
Objective: To assess effect of tranexamic acid on blood loss during and after cesarean section.
Methodology: We performed a randomized controlled trial at Bahawal Victoria Hospital, Bahawalpur from March to December 2013. A total of 120 parturient women with singleton gestation planned to have cesarean section (CS) at ≥37 weeks were randomized to receive 1 g tranexamic acid slowly intravenously over 10 minutes or placebo injection 20 minutes before CS. Blood loss was measured during and for up to two hours after the operation. Any side effects, complications, medications required, and duration of hospital stay were recorded.
Results: Sixty women received transexamic acid and 60 received placebo. Mean blood loss was 260±11 ml vs 485±16 ml in the tranexamic acid group versus the control group (p = 0.003). Only mild, transient adverse effects like nausea and visual disturbances were observed in study group.
Conclusions: Administration of tranexamic acid was associated with reduced blood loss during and after CS. This could be of benefit for anemic women or those who either refuse blood transfusion or can’t arrange donors.

Key words: Tranexamic acid, Cesarean section, blood loss


 
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How to Cite this Article
Pubmed Style

Taj N, Firdaus A, Akhtar N, Chaudhary MH, Sarah , Bajwa Z, Ullah E. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. RMJ. 2014; 39(3): 311-313.

Web Style

Taj N, Firdaus A, Akhtar N, Chaudhary MH, Sarah , Bajwa Z, Ullah E. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. https://www.rmj.org.pk/?mno=151739 [Access: March 14, 2025].

AMA (American Medical Association) Style

Taj N, Firdaus A, Akhtar N, Chaudhary MH, Sarah , Bajwa Z, Ullah E. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. RMJ. 2014; 39(3): 311-313.


Vancouver/ICMJE Style

Taj N, Firdaus A, Akhtar N, Chaudhary MH, Sarah , Bajwa Z, Ullah E. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. RMJ. (2014), [cited March 14, 2025]; 39(3): 311-313.


Harvard Style

Taj, N., Firdaus, . A., Akhtar, . N., Chaudhary, . M. H., Sarah, ., Bajwa, . Z. & Ullah, . E. (2014) Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. RMJ, 39 (3), 311-313.


Turabian Style

Taj, Nergis, Ahsan Firdaus, Nadeem Akhtar, Muhammad Hamid Chaudhary, Sarah, Zunaira Bajwa, and Ehsan Ullah. 2014. Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. Rawal Medical Journal, 39 (3), 311-313.


Chicago Style

Taj, Nergis, Ahsan Firdaus, Nadeem Akhtar, Muhammad Hamid Chaudhary, Sarah, Zunaira Bajwa, and Ehsan Ullah. "Efficacy of tranexamic acid in reducing blood loss during and after cesarean section." Rawal Medical Journal 39 (2014), 311-313.


MLA (The Modern Language Association) Style

Taj, Nergis, Ahsan Firdaus, Nadeem Akhtar, Muhammad Hamid Chaudhary, Sarah, Zunaira Bajwa, and Ehsan Ullah. "Efficacy of tranexamic acid in reducing blood loss during and after cesarean section." Rawal Medical Journal 39.3 (2014), 311-313. Print.


APA (American Psychological Association) Style

Taj, N., Firdaus, . A., Akhtar, . N., Chaudhary, . M. H., Sarah, ., Bajwa, . Z. & Ullah, . E. (2014) Efficacy of tranexamic acid in reducing blood loss during and after cesarean section. Rawal Medical Journal, 39 (3), 311-313.


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