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Original Research
Online Published: 28 Aug 2014
 
RMJ. 2014; 39(3): 265-269


Effect of multiple blood transfusions on hormonal profile in thalassemic children

Mahmood Asif, Zahid Manzoor, Uzma Shaheen, Amama Kanwal, Zia Ur Rahman, Zafar Hussain, Shaukat Hussain Munawar, Imran Ahmad Khan, Abdul Aziz, Muhammad Asif Raza.


Abstract
Objective: To investigate the possible effect of multiple blood transfusions on different hormones with respect to age and sex in thalassemic children.
Methodology: An experimental study was conducted over 12 months in Allied Hospital, Ali Zeb Foundation, and Thalassemia centre in Hilal-e-Ahmar Hospital, Faisalabad. A total number of 80 children were included in this study. They were divided into two groups, containing forty β-thalassemic patients and forty healthy controls. Each group was further subdivided based on sex and age, so that in each subgroup there were ten subjects of same sex with age ranging from 0-5 years and 6-10 years. Blood samples from all the children were withdrawn and analyzed for serum hormones levels of triiodothyronine (T3), thyroxine (T4), testosterone, estradiol and progesterone. All the data was analyzed by using Statistical analysis of variance (ANOVA).
Results: The values of triiodothyronine (T3), thyroxine (T4), testosterone, and estradiol were significantly (p < 0.01) lower irrespective of age and sex in thalassemic children when compared to normal children. However, the progesterone level was significantly (p < 0.01) higher in thalassemic children than normal control.
Conclusions: Multiple blood transfusions induce various endocrinopathies in thalassemic children. Regular evaluation of oxidants and antioxidants status and hormones should be carried out in thalassemic patients during initial few years of life.

Key words: Thalassemia, blood transfusions, hormones, children


 
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How to Cite this Article
Pubmed Style

Asif M, Manzoor Z, Shaheen U, Kanwal A, Rahman ZU, Hussain Z, Munawar SH, Khan IA, Aziz A, Raza MA. Effect of multiple blood transfusions on hormonal profile in thalassemic children. RMJ. 2014; 39(3): 265-269.

Web Style

Asif M, Manzoor Z, Shaheen U, Kanwal A, Rahman ZU, Hussain Z, Munawar SH, Khan IA, Aziz A, Raza MA. Effect of multiple blood transfusions on hormonal profile in thalassemic children. https://www.rmj.org.pk/?mno=153590 [Access: March 14, 2025].

AMA (American Medical Association) Style

Asif M, Manzoor Z, Shaheen U, Kanwal A, Rahman ZU, Hussain Z, Munawar SH, Khan IA, Aziz A, Raza MA. Effect of multiple blood transfusions on hormonal profile in thalassemic children. RMJ. 2014; 39(3): 265-269.


Vancouver/ICMJE Style

Asif M, Manzoor Z, Shaheen U, Kanwal A, Rahman ZU, Hussain Z, Munawar SH, Khan IA, Aziz A, Raza MA. Effect of multiple blood transfusions on hormonal profile in thalassemic children. RMJ. (2014), [cited March 14, 2025]; 39(3): 265-269.


Harvard Style

Asif, M., Manzoor, . Z., Shaheen, . U., Kanwal, . A., Rahman, . Z. U., Hussain, . Z., Munawar, . S. H., Khan, . I. A., Aziz, . A. & Raza, . M. A. (2014) Effect of multiple blood transfusions on hormonal profile in thalassemic children. RMJ, 39 (3), 265-269.


Turabian Style

Asif, Mahmood, Zahid Manzoor, Uzma Shaheen, Amama Kanwal, Zia Ur Rahman, Zafar Hussain, Shaukat Hussain Munawar, Imran Ahmad Khan, Abdul Aziz, and Muhammad Asif Raza. 2014. Effect of multiple blood transfusions on hormonal profile in thalassemic children. Rawal Medical Journal, 39 (3), 265-269.


Chicago Style

Asif, Mahmood, Zahid Manzoor, Uzma Shaheen, Amama Kanwal, Zia Ur Rahman, Zafar Hussain, Shaukat Hussain Munawar, Imran Ahmad Khan, Abdul Aziz, and Muhammad Asif Raza. "Effect of multiple blood transfusions on hormonal profile in thalassemic children." Rawal Medical Journal 39 (2014), 265-269.


MLA (The Modern Language Association) Style

Asif, Mahmood, Zahid Manzoor, Uzma Shaheen, Amama Kanwal, Zia Ur Rahman, Zafar Hussain, Shaukat Hussain Munawar, Imran Ahmad Khan, Abdul Aziz, and Muhammad Asif Raza. "Effect of multiple blood transfusions on hormonal profile in thalassemic children." Rawal Medical Journal 39.3 (2014), 265-269. Print.


APA (American Psychological Association) Style

Asif, M., Manzoor, . Z., Shaheen, . U., Kanwal, . A., Rahman, . Z. U., Hussain, . Z., Munawar, . S. H., Khan, . I. A., Aziz, . A. & Raza, . M. A. (2014) Effect of multiple blood transfusions on hormonal profile in thalassemic children. Rawal Medical Journal, 39 (3), 265-269.


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