ISSN 0303-5212
 
2025, Vol: 50, Issue: 1
50 / 1Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Author_Certificate
Bank Reciept

Original Research
Online Published: 28 Aug 2014
 
RMJ. 2014; 39(3): 331-336


Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero

Gabriel Olaiya Omotoso, Oluwole Busayo Akinola, Bernardd Ufuoma Enaibe, Ezekiel Ademola Caxton-martins.


Abstract
Objective: The safety of nicotine use in pregnancy has been a matter of debate vis-à-vis its effects on the mother and the developing foetus. The current study examined the effect of prenatal nicotine administration during neurodevelopment on some morphometric parameters of neurons and the implication on neurologic functions after birth.
Methods: Twenty female Wistar rats were time mated and grouped into two main groups (A and B), each subdivided into a Control (A1 and B1) and a Treatment subgroup (A2 and B2). Control animals received 0.1 ml normal saline, while treatment groups received 13.76 mg/kg/d nicotine intraperitoneally. Administration was for 5 consecutive days between day 9-13 of the 2nd gestational week (Group A) and day 16-20 of the 3rd gestational week (Group B). At delivery, the weights of the pups were taken and also at postnatal day 15 prior to sacrifice. Animals were anaesthesised with ketamine and perfused transcardially with saline and 4% paraformaldehyde. Tissues were processed for Nissl staining using cresyl fast violet, and analysed for histochemical and morphometric changes.
Results: Findings included low birth weights, altered brain growth pattern, altered neuronal morphology and low neuronal indices.
Conclusions: The neuronal morphological and morphometric changes observed in this study could underlie many of the neurobehavioural abnormalities seen in offspring prenatally exposed to nicotine during neurodevelopment.

Key words: Neurodevelopment, lateral prefrontal cortex, prenatal nicotine


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Gabriel Olaiya Omotoso
Articles by Oluwole Busayo Akinola
Articles by Bernardd Ufuoma Enaibe
Articles by Ezekiel Ademola Caxton-Martins
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Omotoso GO, Akinola OB, Enaibe BU, Caxton-martins EA. Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. RMJ. 2014; 39(3): 331-336.

Web Style

Omotoso GO, Akinola OB, Enaibe BU, Caxton-martins EA. Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. https://www.rmj.org.pk/?mno=154032 [Access: March 13, 2025].

AMA (American Medical Association) Style

Omotoso GO, Akinola OB, Enaibe BU, Caxton-martins EA. Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. RMJ. 2014; 39(3): 331-336.


Vancouver/ICMJE Style

Omotoso GO, Akinola OB, Enaibe BU, Caxton-martins EA. Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. RMJ. (2014), [cited March 13, 2025]; 39(3): 331-336.


Harvard Style

Omotoso, G. O., Akinola, . O. B., Enaibe, . B. U. & Caxton-martins, . E. A. (2014) Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. RMJ, 39 (3), 331-336.


Turabian Style

Omotoso, Gabriel Olaiya, Oluwole Busayo Akinola, Bernardd Ufuoma Enaibe, and Ezekiel Ademola Caxton-martins. 2014. Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. Rawal Medical Journal, 39 (3), 331-336.


Chicago Style

Omotoso, Gabriel Olaiya, Oluwole Busayo Akinola, Bernardd Ufuoma Enaibe, and Ezekiel Ademola Caxton-martins. "Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero." Rawal Medical Journal 39 (2014), 331-336.


MLA (The Modern Language Association) Style

Omotoso, Gabriel Olaiya, Oluwole Busayo Akinola, Bernardd Ufuoma Enaibe, and Ezekiel Ademola Caxton-martins. "Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero." Rawal Medical Journal 39.3 (2014), 331-336. Print.


APA (American Psychological Association) Style

Omotoso, G. O., Akinola, . O. B., Enaibe, . B. U. & Caxton-martins, . E. A. (2014) Neuromorphometric analysis of the lateral prefrontal cortex of young Wistar rats exposed to nicotine in utero. Rawal Medical Journal, 39 (3), 331-336.


Author LoginReviewer LoginEditorial PoliciesConflict of Interest PolicyPlagiarism PolicyAdvertising Policy

About Rawal Medical Journal

Publication, subscription and Editorial office PMA House G/220-B Liaquat Road, Rawalpindi. Phone: 051-555-9812, Fax: 051-553-7088 Email: drnkhokhar@ya ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information