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2025, Vol: 50, Issue: 1
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Review Article 


Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders

Mitra Akbari.


Abstract
In this review study, efficacy and side effects of interferon alfa-2b (IFN-α2b) in treating the common ocular surface disorders is described. It was found that 1 million IU/mL of topical interferon alpha-2b administered four times daily was effective in treating various ocular surface disorders, including vernal keratoconjunctivitis, Ocular surface squamous neoplasia, conjunctival papilloma, and conjunctival melanoma. The treatment showed a significant decrease in symptoms and signs of the diseases and, in some cases, resulted in tumor regression with high tolerance and safety. Irritation was the most common reported adverse effect and complications after treatment with topical IFN-α2b are rare and not severe. IFN-α2b administration intralesionally effectively reduced the conjunctival lymphoma lesions with a dose of 1-1.5 mIU. There is limited reference to mention the effects of this interferon in epidemic keratoconjunctivitis.

Key words: Interferon; interferon alpha-2b; ocular surface disorder; conjunctivitis; pterygium.


 
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How to Cite this Article
Pubmed Style

Mitra Akbari. Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. RMJ. 2025; 50(1): 232-236. doi:10.5455/rmj.20240729063802

Web Style

Mitra Akbari. Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. https://www.rmj.org.pk/?mno=211808 [Access: March 12, 2025]. doi:10.5455/rmj.20240729063802

AMA (American Medical Association) Style

Mitra Akbari. Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. RMJ. 2025; 50(1): 232-236. doi:10.5455/rmj.20240729063802


Vancouver/ICMJE Style

Mitra Akbari. Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. RMJ. (2025), [cited March 12, 2025]; 50(1): 232-236. doi:10.5455/rmj.20240729063802


Harvard Style

Mitra Akbari (2025) Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. RMJ, 50 (1), 232-236. doi:10.5455/rmj.20240729063802


Turabian Style

Mitra Akbari. 2025. Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. Rawal Medical Journal, 50 (1), 232-236. doi:10.5455/rmj.20240729063802


Chicago Style

Mitra Akbari. "Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders." Rawal Medical Journal 50 (2025), 232-236. doi:10.5455/rmj.20240729063802


MLA (The Modern Language Association) Style

Mitra Akbari. "Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders." Rawal Medical Journal 50.1 (2025), 232-236. Print. doi:10.5455/rmj.20240729063802


APA (American Psychological Association) Style

Mitra Akbari (2025) Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders. Rawal Medical Journal, 50 (1), 232-236. doi:10.5455/rmj.20240729063802


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