ISSN 0303-5212
 

Review Article 


Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials

Herwindo Ahmad, Refli Hasan, Naomi Niari Dalimunthe, Rahmad Isnanta, T. Realsyah, Zainal Safri.


Abstract
Hypertension is the primary risk factor for kidney and cardiovascular disease. Effective control of hypertension is important as reduction of blood pressure may effectively mitigate cardiovascular risks. The prevalence of uncontrolled hypertension persists, despite the widespread availability of antihypertensive medications. Poor adherence to medications is attributed to inadequate blood pressure control with current treatments. Zilebesiran, an investigational RNA interference therapeutic agent, targets hepatic angiotensinogen synthesis to provide sustained blood pressure reduction. It provides long-lasting pharmacological effects, requiring only twice a year or quarterly subcutaneous injection. Therefore, it is feasible to tackle the inadequate patient compliance with this drug. This review discusses its potential clinical impact, efficacy, and safety profile based on recent studies.

Key words: siRNA, hypertension, antihypertensive agents.


 
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How to Cite this Article
Pubmed Style

Ahmad H, Hasan R, Dalimunthe NN, Isnanta R, Realsyah T, Safri Z. Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. RMJ. 2025; 50(3): 779-783. doi:10.5455/rmj.20250324021049


Web Style

Ahmad H, Hasan R, Dalimunthe NN, Isnanta R, Realsyah T, Safri Z. Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. https://www.rmj.org.pk/?mno=249091 [Access: October 30, 2025]. doi:10.5455/rmj.20250324021049


AMA (American Medical Association) Style

Ahmad H, Hasan R, Dalimunthe NN, Isnanta R, Realsyah T, Safri Z. Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. RMJ. 2025; 50(3): 779-783. doi:10.5455/rmj.20250324021049



Vancouver/ICMJE Style

Ahmad H, Hasan R, Dalimunthe NN, Isnanta R, Realsyah T, Safri Z. Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. RMJ. (2025), [cited October 30, 2025]; 50(3): 779-783. doi:10.5455/rmj.20250324021049



Harvard Style

Ahmad, H., Hasan, . R., Dalimunthe, . N. N., Isnanta, . R., Realsyah, . T. & Safri, . Z. (2025) Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. RMJ, 50 (3), 779-783. doi:10.5455/rmj.20250324021049



Turabian Style

Ahmad, Herwindo, Refli Hasan, Naomi Niari Dalimunthe, Rahmad Isnanta, T. Realsyah, and Zainal Safri. 2025. Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. Rawal Medical Journal, 50 (3), 779-783. doi:10.5455/rmj.20250324021049



Chicago Style

Ahmad, Herwindo, Refli Hasan, Naomi Niari Dalimunthe, Rahmad Isnanta, T. Realsyah, and Zainal Safri. "Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials." Rawal Medical Journal 50 (2025), 779-783. doi:10.5455/rmj.20250324021049



MLA (The Modern Language Association) Style

Ahmad, Herwindo, Refli Hasan, Naomi Niari Dalimunthe, Rahmad Isnanta, T. Realsyah, and Zainal Safri. "Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials." Rawal Medical Journal 50.3 (2025), 779-783. Print. doi:10.5455/rmj.20250324021049



APA (American Psychological Association) Style

Ahmad, H., Hasan, . R., Dalimunthe, . N. N., Isnanta, . R., Realsyah, . T. & Safri, . Z. (2025) Zilebesiran, a Small Interfering RNA agent as a potential novel antihypertensive treatment with cardiorenal protective effects: An overview of recent clinical trials. Rawal Medical Journal, 50 (3), 779-783. doi:10.5455/rmj.20250324021049