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Original Research
Online Published: 29 Sep 2016
 
RMJ. 2016; 41(3): 342-345


Leptin as an early pregnancy marker for pregnancy induced hypertension

Huma Tasleem, Tasneem Akhter, Haider Ghazanfar, Samina Tasleem, Salman Assad.


Abstract
Objectives: To study the role of serum leptin as an early pregnancy marker for pre-eclampsia.
Methodology: A total of 1300 patients were selected for the study. 79 (6%) were lost to follow-up. Out of 1221 patients, 134 (10.9%) patients developed pre-eclampsia, 1087 (89.1%) remained normotensive. Patients included in the study had confirmed intrauterine pregnancy with ultrasound, either normotensive or ≥140/90 mmHg, 24-hour urine proteinuria >300mg or ratio of protein to creatinine >30mg/mmol. Patients with pre-eclampsia in the previous pregnancy and twin pregnancy were not included in the study. Blood samples were taken at the gestational age of 16 weeks and serum leptin level was measured by ELISA.
Result: Mean age of the pre-eclampsia group was 27.54±4.50 years and for the normal pregnancy group was 27.65±4.62 years. Mean leptin value in the pre-eclampsia group was 64.38±12.77ng/ml while in normal group it was 63.64±33.58 ng/ml (p>0.05). Cesarean rate was higher in the pre-eclampsia group (14.9%) as compared to normal pregnancy group (8.9%).
Conclusion: Serum leptin levels were found to be similar in the patients with preeclampsia and normotensive pregnant women.

Key words: Biomarkers, leptin, pre-eclampsia, proteinuria.


 
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How to Cite this Article
Pubmed Style

Tasleem H, Akhter T, Ghazanfar H, Tasleem S, Assad S. Leptin as an early pregnancy marker for pregnancy induced hypertension. RMJ. 2016; 41(3): 342-345.

Web Style

Tasleem H, Akhter T, Ghazanfar H, Tasleem S, Assad S. Leptin as an early pregnancy marker for pregnancy induced hypertension. https://www.rmj.org.pk/?mno=223468 [Access: June 23, 2026].

AMA (American Medical Association) Style

Tasleem H, Akhter T, Ghazanfar H, Tasleem S, Assad S. Leptin as an early pregnancy marker for pregnancy induced hypertension. RMJ. 2016; 41(3): 342-345.


Vancouver/ICMJE Style

Tasleem H, Akhter T, Ghazanfar H, Tasleem S, Assad S. Leptin as an early pregnancy marker for pregnancy induced hypertension. RMJ. (2016), [cited June 23, 2026]; 41(3): 342-345.


Harvard Style

Tasleem, H., Akhter, . T., Ghazanfar, . H., Tasleem, . S. & Assad, . S. (2016) Leptin as an early pregnancy marker for pregnancy induced hypertension. RMJ, 41 (3), 342-345.


Turabian Style

Tasleem, Huma, Tasneem Akhter, Haider Ghazanfar, Samina Tasleem, and Salman Assad. 2016. Leptin as an early pregnancy marker for pregnancy induced hypertension. Rawal Medical Journal, 41 (3), 342-345.


Chicago Style

Tasleem, Huma, Tasneem Akhter, Haider Ghazanfar, Samina Tasleem, and Salman Assad. "Leptin as an early pregnancy marker for pregnancy induced hypertension." Rawal Medical Journal 41 (2016), 342-345.


MLA (The Modern Language Association) Style

Tasleem, Huma, Tasneem Akhter, Haider Ghazanfar, Samina Tasleem, and Salman Assad. "Leptin as an early pregnancy marker for pregnancy induced hypertension." Rawal Medical Journal 41.3 (2016), 342-345. Print.


APA (American Psychological Association) Style

Tasleem, H., Akhter, . T., Ghazanfar, . H., Tasleem, . S. & Assad, . S. (2016) Leptin as an early pregnancy marker for pregnancy induced hypertension. Rawal Medical Journal, 41 (3), 342-345.


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