Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis

Tanzeel Imran; Lubna Zafar; Humera Naz Altaf; Saif Orakzai; Tariq Butt; Farid Bakhtiar

2026, Vol: 51, Issue: 2

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Original Research

RMJ. 2017; 42(3): 302-305

Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis

Tanzeel Imran, Lubna Zafar, Humera Naz Altaf, Saif Orakzai, Tariq Butt, Farid Bakhtiar.

Abstract
Objective: To establish the diagnostic effectiveness of platelets parameters i.e. platelets distribution width (PDW) and mean platelet volume (MPV) in differential diagnosis of thrombocytosis (clonal thrombocytosis /reactive thrombocytosis).
Methodology: This cross-sectional study was carried out at Hematology department at Fauji Foundation Hospital, Rawalpindi, Pakistan from Feb 2012 to March 2013. A total of 148 patients were studied. Out of these, equal number had myeloproliferative disorders (MPD) and reactive thrombocytosis (RT). The complete blood picture was done on auto-analyzer Sysmex XT (2000i) and platelet count, PDW and MPV were determined.
Results: Out of 148 patients with thrombocytosis, the range of PDW was 10-20 % for clonal thrombocytosis (CT) with a mean value of 14.3±2.2% and for RT the range of PDW was 7-13% and the mean value was 9±1.3%. The mean MPV for CT was 11.7±1.6fl and for RT was 8.50±0.6fl with a range of 8.7-18.5fl for CT and 7.2-10.4fl for RT. The t test was applied on the mean of MPV and PDW of clonal and reactive thrombocytosis (p<0.0001), which was statistically significant.
Conclusion: Interpretation of platelet parameters i.e. PDW and MPV with platelet counts are useful for the differentiating CT from RT. By increasing awareness of our clinicians in utilizing these simple parameters will aid in diagnosis of CT when platelets counts are markedly elevated.

Key words: Clonal thrombocytosis, Reactive thrombocytosis, platelets distribution width PDW, Mean platelet volume MPV.

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Pubmed Style

Imran T, Zafar L, Altaf HN, Orakzai S, Butt T, Bakhtiar F. Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis. RMJ. 2017; 42(3): 302-305.

Web Style

Imran T, Zafar L, Altaf HN, Orakzai S, Butt T, Bakhtiar F. Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis. https://www.rmj.org.pk/?mno=241206 [Access: June 23, 2026].

AMA (American Medical Association) Style

Imran T, Zafar L, Altaf HN, Orakzai S, Butt T, Bakhtiar F. Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis. RMJ. 2017; 42(3): 302-305.

Vancouver/ICMJE Style

Harvard Style

Imran, T., Zafar, . L., Altaf, . H. N., Orakzai, . S., Butt, . T. & Bakhtiar, . F. (2017) Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis. RMJ, 42 (3), 302-305.

Turabian Style

Imran, Tanzeel, Lubna Zafar, Humera Naz Altaf, Saif Orakzai, Tariq Butt, and Farid Bakhtiar. 2017. Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis. Rawal Medical Journal, 42 (3), 302-305.

Chicago Style

Imran, Tanzeel, Lubna Zafar, Humera Naz Altaf, Saif Orakzai, Tariq Butt, and Farid Bakhtiar. "Evaluation of platelet parameters (PDW and MPV) for differentiation between clonal thrombocytosis and reactive thrombocytosis." Rawal Medical Journal 42 (2017), 302-305.

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