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Original Research 
RMJ. 2026; 51(2): 348-351


A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease

Malik Istikhar Ali Sajjad, Bushra Ujala, Mehvish Aqil, Mehr Muhammad Imran, Usman Khalid, Amina Manzoor.


Abstract
Objective: To investigate the relationship between quantitative computed tomography (QCT) parameters and clinical phenotypes in patients with stable chronic obstructive pulmonary disease COPD.
Methodology: This cross-sectional study included 60 patients clinically diagnosed with COPD. Demographic and clinical characteristics such as age, sex, smoking status, and body mass index (BMI) were recorded. Spirometry measurements, particularly forced expiratory volume in one second (FEV1), modified Medical Research Council (mMRC) dyspnea assessment, and six-minute walk distance (6MWD) were noted to evaluate lung function. Chest CT scans were obtained in all patients, and QCT analysis was performed to obtain the emphysema index, percent air trapping, airway wall thickness, and mean lung density. The Pearson correlation and linear regression analyses were performed via SPSS version 26.
Results: The average age was 65.3±9.4 years, and 70% of participants were male. The mean emphysema index was 32.4%, and air trapping was 29.1%. The emphysema index had a significant negative correlation with FEV1 (r = -0.58, p<0.05), and air trapping was moderately inversely correlated with 6MWD (r = -0.45, p<0.05). The mMRC scores were higher in relation to the increased emphysema and air trapping. The thickness of airway walls showed a non-significant, modest correlation with clinical severity.
Conclusion: Quantitative CT offers clinically relevant information on the structural changes of the lungs in COPD patients and is associated with a strong correlation with functional limitation, exercise capacity, and symptom load.

Key words: Pulmonary disease, chronic obstructive, tomography, emphysema, airway obstruction.


 
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How to Cite this Article
Pubmed Style

Sajjad MIA, Ujala B, Aqil M, Imran MM, Khalid U, Manzoor A. A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. RMJ. 2026; 51(2): 348-351.

Web Style

Sajjad MIA, Ujala B, Aqil M, Imran MM, Khalid U, Manzoor A. A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. https://www.rmj.org.pk/?mno=264394 [Access: June 23, 2026].

AMA (American Medical Association) Style

Sajjad MIA, Ujala B, Aqil M, Imran MM, Khalid U, Manzoor A. A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. RMJ. 2026; 51(2): 348-351.


Vancouver/ICMJE Style

Sajjad MIA, Ujala B, Aqil M, Imran MM, Khalid U, Manzoor A. A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. RMJ. (2026), [cited June 23, 2026]; 51(2): 348-351.


Harvard Style

Sajjad, M. I. A., Ujala, . B., Aqil, . M., Imran, . M. M., Khalid, . U. & Manzoor, . A. (2026) A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. RMJ, 51 (2), 348-351.


Turabian Style

Sajjad, Malik Istikhar Ali, Bushra Ujala, Mehvish Aqil, Mehr Muhammad Imran, Usman Khalid, and Amina Manzoor. 2026. A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. Rawal Medical Journal, 51 (2), 348-351.


Chicago Style

Sajjad, Malik Istikhar Ali, Bushra Ujala, Mehvish Aqil, Mehr Muhammad Imran, Usman Khalid, and Amina Manzoor. "A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease." Rawal Medical Journal 51 (2026), 348-351.


MLA (The Modern Language Association) Style

Sajjad, Malik Istikhar Ali, Bushra Ujala, Mehvish Aqil, Mehr Muhammad Imran, Usman Khalid, and Amina Manzoor. "A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease." Rawal Medical Journal 51.2 (2026), 348-351. Print.


APA (American Psychological Association) Style

Sajjad, M. I. A., Ujala, . B., Aqil, . M., Imran, . M. M., Khalid, . U. & Manzoor, . A. (2026) A cross-sectional evaluation of quantitative CT parameters correlated with clinical phenotypes in chronic obstructive pulmonary disease. Rawal Medical Journal, 51 (2), 348-351.


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