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Original Research
Online Published: 04 Oct 2026
 


Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort

Ambreen Zahra, Sultan Habibullah Khan, Amen Shamim, Muhammad Imran Arshad.


Abstract
Objective: To assess the evidence for the OAS1 rs10774671 genetic variant association with COVID-19 severity and associated risk factors in the Pakistani population.
Methodology: In this analytical cross-sectional study, 200 PCR-confirmed COVID-19 patients were genotyped by TaqMan real-time PCR, with 6% of samples validated by Sanger sequencing. Associations were assessed using Chi-square tests and multivariable logistic regression adjusted for age, sex, BMI, and comorbidities.
Results: Participants had AA (75), AG (71), and GG (54) genotypes. The AA genotype demonstrated nearly a 3-fold higher likelihood of developing severe COVID-19 compared to the mild/moderate group (OR=2.99; 95% CI=1.30–6.86; p=0.0073). Among 143 active COVID-19 patients (71 severe and 72 mild/moderate), higher BMI (aOR=1.20 per kg/m², 95% CI: 1.1–1.32; p<0.001), comorbidity (aOR=9.22, 95% CI: 1.88–45.18; p<0.0006), were independently associated with severe COVID-19, whereas age and sex were not.
Conclusion: OAS1 rs10774671 was associated with COVID-19 severity, with the AA more prevalent among severe cases.

Key words: Genetic risk factors, single nucleotide polymorphism, OAS1, COVID-19.


 
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How to Cite this Article
Pubmed Style

Zahra A, Khan SH, Shamim A, Arshad MI. Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. RMJ. Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803

Web Style

Zahra A, Khan SH, Shamim A, Arshad MI. Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. https://www.rmj.org.pk/?mno=316702 [Access: October 05, 2026]. doi:10.5455/rmj.20260407052803

AMA (American Medical Association) Style

Zahra A, Khan SH, Shamim A, Arshad MI. Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. RMJ. Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


Vancouver/ICMJE Style

Zahra A, Khan SH, Shamim A, Arshad MI. Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. RMJ, [cited October 05, 2026]; Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


Harvard Style

Zahra, A., Khan, . S. H., Shamim, . A. & Arshad, . M. I. (2026) Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. RMJ, Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


Turabian Style

Zahra, Ambreen, Sultan Habibullah Khan, Amen Shamim, and Muhammad Imran Arshad. 2026. Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. Rawal Medical Journal, Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


Chicago Style

Zahra, Ambreen, Sultan Habibullah Khan, Amen Shamim, and Muhammad Imran Arshad. "Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort." Rawal Medical Journal Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


MLA (The Modern Language Association) Style

Zahra, Ambreen, Sultan Habibullah Khan, Amen Shamim, and Muhammad Imran Arshad. "Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort." Rawal Medical Journal Online First: 04 Oct, 2026. Web. 05 Oct 2026 doi:10.5455/rmj.20260407052803


APA (American Psychological Association) Style

Zahra, A., Khan, . S. H., Shamim, . A. & Arshad, . M. I. (2026) Association of OAS1 rs10774671 Polymorphism with COVID-19 severity in a Pakistani cohort. Rawal Medical Journal, Online First: 04 Oct, 2026. doi:10.5455/rmj.20260407052803


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