Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan

Mir Tahir Hussain Talpur; Mushtaque Ahmed Khoso; Muhammad Ali; Khalil Ullah Shabbir; Sagheer Ahmed Solangi; Uzair Yaqoob

2026, Vol: 51, Issue: 2

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RMJ. 2019; 44(4): 666-669

Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan

Mir Tahir Hussain Talpur, Mushtaque Ahmed Khoso, Muhammad Ali, Khalil Ullah Shabbir, Sagheer Ahmed Solangi, Uzair Yaqoob.

Abstract
Objective: To find the prevalence of hyperpigmentation in patients with megaloblastic anemia in Karachi population.
Methodology: This study was conducted at Jinnah Postgraduate Medical Center, Karachi from March to August 2018. A total of 103 megaloblastic anemia patients were included. A detailed history was recorded and patients were examined for hyperpigmented lesions and other cutaneous manifestations. Data were analyzed through SPSS version 23.
Results: The mean hemoglobin level was 7.8±1.2 g/dl. Out of 103 patients, 32 (31%) had hyperpigmentation and 71 (69%) were negative for hyperpigmentation. 30 (93.75%) patients had multiple lesions while only 2 (6.25%) had a single hyperpigmented lesion. Majority of patients (87.49%) had lesions that were 1-5mm in size, 3 (9.38%) had lesions of size 6-10mm, while none had a lesion exceeding 10mm in diameter. The distribution of pigmented lesions was most pronounced in the forehead, neck, arms, legs and back.
Conclusion: We highly advocate that patients with any pigmented changes should be assessed for B12 deficiency. Early detection and proper management can help prevent partially irreversible neurological deficits that results from prolonged deficiency of Vitamin B12.

Key words: Anemia, megaloblastic anemia, hyperpigmentation, B12 deficiency, folate.

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How to Cite this Article

Pubmed Style

Talpur MTH, Khoso MA, Ali M, Shabbir KU, Solangi SA, Yaqoob U. Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan. RMJ. 2019; 44(4): 666-669.

Web Style

Talpur MTH, Khoso MA, Ali M, Shabbir KU, Solangi SA, Yaqoob U. Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan. https://www.rmj.org.pk/?mno=48707 [Access: June 27, 2026].

AMA (American Medical Association) Style

Talpur MTH, Khoso MA, Ali M, Shabbir KU, Solangi SA, Yaqoob U. Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan. RMJ. 2019; 44(4): 666-669.

Vancouver/ICMJE Style

Harvard Style

Talpur, M. T. H., Khoso, . M. A., Ali, . M., Shabbir, . K. U., Solangi, . S. A. & Yaqoob, . U. (2019) Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan. RMJ, 44 (4), 666-669.

Turabian Style

Talpur, Mir Tahir Hussain, Mushtaque Ahmed Khoso, Muhammad Ali, Khalil Ullah Shabbir, Sagheer Ahmed Solangi, and Uzair Yaqoob. 2019. Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan. Rawal Medical Journal, 44 (4), 666-669.

Chicago Style

Talpur, Mir Tahir Hussain, Mushtaque Ahmed Khoso, Muhammad Ali, Khalil Ullah Shabbir, Sagheer Ahmed Solangi, and Uzair Yaqoob. "Frequency of hyperpigmentation in patients with megaloblastic anemia: A cross-sectional study from a tertiary care hospital of Pakistan." Rawal Medical Journal 44 (2019), 666-669.

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