Abstract
Abstract
Objective: To analysed the serum Testosterone in obese and Diabetes Mellitus Type-II Males individuals.
Study design: A Cross-Sectional Comparative Study.
Place and Duration of Study: The patients were recruited from Department of Medicine unit-II Liaquat hospital Jamshoro and analysis at Institute of Biotechnology and Genetic Engineering, University of Sindh, Jamshoro during the period of April 2018 to September 2018.
Methodology: Total 150 males were included in this study and divided into three group, out of which Group A: n=50 were healthy normal males, Group B: n=50 were obese males(BMI>25) and Group C: n=50 were Type II- diabetic males ages 20-70 years old. Blood sample were collected from the all participants for performing various biochemical tests Fasting blood sugar (FBS)and Random blood sugar (RBS), HbA1c, Insulin, Testosterone by filling Performa and written consent by explaining them about study purpose. The ANOVA test was applied for the analysis of continuous variables. Statistical significance was defined as p-value of ≤ 0.05.
Results: We found significant results of FBS, RBS and HbA1c in T2DM patient as compared to control, but the fasting and HbA1c on upper limit in obese group (p<0.001). Serum Insulin and serum testosterone was declined significantly in group C as compared to control group. The BMI of group B and C was increase as compared to control group (p<0.001). We also observed waist/hip ratio in obese and T2 diabetic males having (p<0.001) as compared to control.
Conclusion: Obesity is considered as a most serious community health problem. Significant impact of obesity mediate susceptibility to develop Type-II Diabetes mellitus and decrease levels of serum testosterone in males. Early screening and weight reduction by exercise will be helpful in prevention of T2DM in males and enhance their quality of life by maintaining their testosterone level.

Key words: T2DM, Testosterone, Insulin, BMI, HbA1c.