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2025, Vol: 50, Issue: 4
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Original Research 
RMJ. 2025; 50(3): 704-707


Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma

Ayesha Zahir, Sadaf Ahmed Asim, Madiha Sajid, Tayyaba Iqbal, Ruba Khan, Sharmin Nasir.


Abstract
Objective: To determine the efficacy and safety of 100mg/ml intradermal tranexamic acid for the treatment of melasma.
Methodology: The study was conducted at Department of Dermatology, Dow University Hospital, Ojha campus, Karachi from 1st September 2023 to 29th February 2024 and included 60 patients selected by non-probability consecutive sampling technique. All diagnosed patients of melasma were included in the study. A detailed demographic and medical history were taken along with the Wood’s lamp examination. We administered 100mg/ml tranexamic undiluted injection intradermally at the site of melasma. A total of six sessions were carried out every 2 weeks for 3 months. Modified Melasma Area and Severity Index (mMASI) score was calculated on the first and last visit to evaluate efficacy of treatment.
Results: At first visit mean of mMASI was 6.43±3.57 (range 1.2-18.0), which showed significant reduction to 3.94±2.74 (range 0.3-13.8) at last visit (p<0.001). Efficacy of intradermal tranexamic acid was excellent in 8 (13.3%) patients, good in 10 (16.7%), fair in 33 (55.0%) and poor in 9 (15.0%) patients. Temporary redness, pain and localized bumps were noted as temporary side effects.
Conclusion: Higher dose of intradermal tranexamic acid (100mg/ml) was a safe and effective therapy for the treatment of melasma.

Key words: Melasma, mesotherapy, tranexamic acid.


 
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How to Cite this Article
Pubmed Style

Zahir A, Asim SA, Sajid M, Iqbal T, Khan R, Nasir S. Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. RMJ. 2025; 50(3): 704-707.

Web Style

Zahir A, Asim SA, Sajid M, Iqbal T, Khan R, Nasir S. Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. https://www.rmj.org.pk/?mno=214320 [Access: October 30, 2025].

AMA (American Medical Association) Style

Zahir A, Asim SA, Sajid M, Iqbal T, Khan R, Nasir S. Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. RMJ. 2025; 50(3): 704-707.


Vancouver/ICMJE Style

Zahir A, Asim SA, Sajid M, Iqbal T, Khan R, Nasir S. Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. RMJ. (2025), [cited October 30, 2025]; 50(3): 704-707.


Harvard Style

Zahir, A., Asim, . S. A., Sajid, . M., Iqbal, . T., Khan, . R. & Nasir, . S. (2025) Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. RMJ, 50 (3), 704-707.


Turabian Style

Zahir, Ayesha, Sadaf Ahmed Asim, Madiha Sajid, Tayyaba Iqbal, Ruba Khan, and Sharmin Nasir. 2025. Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. Rawal Medical Journal, 50 (3), 704-707.


Chicago Style

Zahir, Ayesha, Sadaf Ahmed Asim, Madiha Sajid, Tayyaba Iqbal, Ruba Khan, and Sharmin Nasir. "Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma." Rawal Medical Journal 50 (2025), 704-707.


MLA (The Modern Language Association) Style

Zahir, Ayesha, Sadaf Ahmed Asim, Madiha Sajid, Tayyaba Iqbal, Ruba Khan, and Sharmin Nasir. "Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma." Rawal Medical Journal 50.3 (2025), 704-707. Print.


APA (American Psychological Association) Style

Zahir, A., Asim, . S. A., Sajid, . M., Iqbal, . T., Khan, . R. & Nasir, . S. (2025) Efficacy and safety of 100mg/ml tranexamic acid mesotherapy for the treatment of melasma. Rawal Medical Journal, 50 (3), 704-707.


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