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Original Research
Online Published: 08 Aug 2021
 
RMJ. 2021; 46(3): 538-541


Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children

Nafisa Nihal, Rukhshan Khurshid, Uzma Jabbar, Naim Ahmad Nizami, Maira Mahmood, Hafiza Hina Pasha.


Abstract
Objective: To find the correlation of Interleukins (IL) with impaired fasting glucose and insulin resistance in female beta thalassemic children.
Methodology: Thirty-five female children of Beta thalassemia major with impair fasting blood glucose were taken as group A and 35 beta thalassemic children with normal blood glucose were taken as control (group B). Age range was 10-12 years. Level of fasting blood glucose, serum insulin, ferritin, IL 1, 2, 4, & 13 were estimated.
Results: Mean level of serum IL-1 was increased along with decreased values of IL 2, IL 4 & IL 13 in group A in comparison with group B. Mean levels of fasting serum insulin in group A was significantly increased in comparison with group B. Values of insulin resistance in group A and group B were 2.9 and 0.7, respectively.
Conclusion: An indirect link of impaired fasting glucose and insulin resistance with interleukins may increase the risk of developing type 1 diabetes in children with thalassemia major on long-term blood transfusion. However, further study is needed on large number of both genders to reach a better conclusion.

Key words: Interleukins, beta thalassemia major, blood glucose.


 
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How to Cite this Article
Pubmed Style

Nihal N, Khurshid R, Jabbar U, Nizami NA, Mahmood M, Pasha HH. Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . RMJ. 2021; 46(3): 538-541.

Web Style

Nihal N, Khurshid R, Jabbar U, Nizami NA, Mahmood M, Pasha HH. Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . https://www.rmj.org.pk/?mno=107926 [Access: June 23, 2026].

AMA (American Medical Association) Style

Nihal N, Khurshid R, Jabbar U, Nizami NA, Mahmood M, Pasha HH. Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . RMJ. 2021; 46(3): 538-541.


Vancouver/ICMJE Style

Nihal N, Khurshid R, Jabbar U, Nizami NA, Mahmood M, Pasha HH. Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . RMJ. (2021), [cited June 23, 2026]; 46(3): 538-541.


Harvard Style

Nihal, N., Khurshid, . R., Jabbar, . U., Nizami, . N. A., Mahmood, . M. & Pasha, . H. H. (2021) Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . RMJ, 46 (3), 538-541.


Turabian Style

Nihal, Nafisa, Rukhshan Khurshid, Uzma Jabbar, Naim Ahmad Nizami, Maira Mahmood, and Hafiza Hina Pasha. 2021. Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . Rawal Medical Journal, 46 (3), 538-541.


Chicago Style

Nihal, Nafisa, Rukhshan Khurshid, Uzma Jabbar, Naim Ahmad Nizami, Maira Mahmood, and Hafiza Hina Pasha. "Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children ." Rawal Medical Journal 46 (2021), 538-541.


MLA (The Modern Language Association) Style

Nihal, Nafisa, Rukhshan Khurshid, Uzma Jabbar, Naim Ahmad Nizami, Maira Mahmood, and Hafiza Hina Pasha. "Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children ." Rawal Medical Journal 46.3 (2021), 538-541. Print.


APA (American Psychological Association) Style

Nihal, N., Khurshid, . R., Jabbar, . U., Nizami, . N. A., Mahmood, . M. & Pasha, . H. H. (2021) Levels of interleukins in pre-diabetic and non-diabetic beta thalassemic children . Rawal Medical Journal, 46 (3), 538-541.


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